Baumberg directs the NanoPhotonics Centre, confining light into sub-nanometre plasmonic 'picocavities' between metal nanostructures to achieve single-molecule-sensitive SERS and study light-matter coupling at the molecular scale. Current work spans low-cost healthcare biosensors, chiral nanophotonics and quantum coherent effects in plasmonic cavities.
Poul Martin Bendix (Associate Professor, BendixLab/NBI) investigates physical properties of living cells using advanced optical techniques. Research: (1) optical tweezers for mechanosensing — GPCR mechanosensing with picoNewton force resolution, membrane curvature sensing by proteins (annexins, BAR-domain proteins); (2) thermoplasmonics — gold nanoparticle laser heating for controlled membrane microsurgery, cell fusion, and plasma membrane repair; (3) single-molecule biophysics — DNA-protein interactions using 4-trap optical tweezers (LUMICKS C-Trap) with STED imaging; (4) filopodia dynamics — twist and rotation of actin filaments; (5) Brillouin microscopy for cell mechanics; (6) COBM center management. GPCRmec consortium (Novo Nordisk). 2026 BPS Annual Meeting featured.
De Nijs leads the Physics for Sustainable Chemistry group, studying light-matter interactions at molecular length-scales using plasmonic nanocavities, with applications spanning single-molecule SERS sensing, in-situ electrochemical monitoring, and plasmon-driven photocatalysis for green chemistry (e.g. plastics degradation).
Nynke Dekker (Full Professor, BioNanoscience) leads single-molecule biophysics of DNA replication and topology. Research: (1) single-molecule force-fluorescence microscopy — integrated optical tweezers and fluorescence for real-time imaging of replication machinery; (2) DNA topology — supercoiling, gyrase, topoisomerase dynamics with magnetic tweezers; (3) DNA/RNA-processing molecular motors. EMBO member; KNAW member. 2024 integrated force-fluorescence toolbox published.
Kristin Grußmayer (Assistant Professor, BioNanoscience, 2021) develops super-resolution microscopy tools. Research: (1) SOFI (super-resolution optical fluctuation imaging) — camera-based super-resolution using photon statistics; (2) multi-plane super-resolution and quantitative phase imaging — combined modalities for 3D sub-diffraction imaging; (3) new fluorescence probe classes for SMLM; (4) AI-driven smart microscopy for automated phenotype detection. Marie Curie Fellow (EPFL, Lasser group). Group established 2021.
Thomas Heimburg (Professor, NBI Membranes group) works on thermodynamics and biophysics of biological membranes. Research: (1) theory of nerve pulse propagation as electromechanical solitons ('soliton model'); (2) lipid membrane phase transitions — calorimetry, DSC, AFM; (3) anesthesia mechanism via membrane phase perturbation; (4) ion-channel-like events in pure lipid membranes near phase transitions. Notably co-authored 2016 Scientific Reports paper with QUANTOP (Jensen et al.) demonstrating non-invasive detection of nerve impulses using atomic magnetometry — direct overlap with quantum sensing.
Gijsje Koenderink (Full Professor, BioNanoscience) investigates active and passive mechanics of the cytoskeleton. Research: (1) active matter — motor-filament composite networks generating spontaneous mechanical activity; (2) cell mechanics — cytoskeletal contributions to cell shape, migration, and division; (3) biomaterials — designing synthetic cytoskeletal analogues; (4) optical tweezers and AFM rheology of reconstituted networks. Spinoza Prize 2021. ERC Advanced Grant.
Winpenny holds the Regius Chair in Chemistry at Manchester and is a world leader in molecular magnetism and molecular nanomagnets for quantum technologies. Research directions: (1) Molecular nanomagnets — synthesis of Cr7Ni 'horseshoe' rings and related cage clusters as prototype molecular qubits with long T2 times; (2) Multi-qubit molecular architectures — covalently linked molecular qubit pairs and arrays for quantum gate operations and distributed sensing; (3) Quantum error correction in molecules — designing molecular systems encoding logical qubits with error protection; (4) Quantum sensing applications — molecular spin systems as ultra-sensitive nanoscale magnetic sensors in the sub-nm regime. Leading the NPL M4Q Network and UK molecular qubit community.
Yakovlev develops label-free biomedical imaging: Brillouin micro-spectroscopy of cell/tissue viscoelasticity, impulsive stimulated Brillouin scattering, SERS and coherent-Raman diagnostics, and quantum-enhanced (photon-number-resolving, sub-shot-noise) optical imaging in collaboration with Agarwal/Scully. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work provides the biomedical, quantum-enhanced-imaging bridge for spin-sensor bio-applications.