Research Areas - (4) Lanthanide Luminescence / Time-Gated Biosensing

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Lanthanide Luminescence / Time-Gated Biosensing

Department(s)/lab(s): Chemistry | PPSM - Luminescent Molecular Materials (Allain) @ ENSPS
Summary:

Allain (PPSM) designs luminescent and mechanofluorochromic molecular materials and lanthanide/organic probes acting as optical stress and environment sensors, including solid-state and time-resolved luminescence readouts. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is complemented by stimuli-responsive molecular luminescent sensors.

Department(s)/lab(s): Physics / Niels Bohr Institute | BendixLab — Biophotonics & Mechanobiology @ UCPH
Summary:

Poul Martin Bendix (Associate Professor, BendixLab/NBI) investigates physical properties of living cells using advanced optical techniques. Research: (1) optical tweezers for mechanosensing — GPCR mechanosensing with picoNewton force resolution, membrane curvature sensing by proteins (annexins, BAR-domain proteins); (2) thermoplasmonics — gold nanoparticle laser heating for controlled membrane microsurgery, cell fusion, and plasma membrane repair; (3) single-molecule biophysics — DNA-protein interactions using 4-trap optical tweezers (LUMICKS C-Trap) with STED imaging; (4) filopodia dynamics — twist and rotation of actin filaments; (5) Brillouin microscopy for cell mechanics; (6) COBM center management. GPCRmec consortium (Novo Nordisk). 2026 BPS Annual Meeting featured.

Department(s)/lab(s): Chemistry – Photon Science Institute / National EPR Facility | Bowen Group (Molecular Spin Qubits and EPR) @ Manchester
Summary:

Bowen leads the CQSE 'Spins and Qubits' theme at Manchester, focusing on organometallic molecular spin qubits for quantum sensing and computing. Research directions: (1) Organometallic La(II) and other rare-earth molecular qudits — designing molecules with multiple accessible spin states (qudits) for encoding quantum information and sensing; (2) Pulsed EPR characterization — Hahn echo, ESEEM, ENDOR at X/W/Q-band to measure coherence times and hyperfine couplings; (3) Integration of molecular qubits into devices — surface deposition and nanoscale addressing; (4) Multi-spin sensing — using exchange-coupled spin pairs as differential sensors of magnetic field gradients. Closely collaborates with Tuna and Winpenny.

Department(s)/lab(s): Graduate School of Biomedical Engineering | Goldys Nanoscale Biophotonics Group @ UNSW
Summary:

Goldys was Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics and now leads a nanoscale biophotonics group in Biomedical Engineering. The programme is about extracting diagnostic information from very weak optical signals inside cells and tissue: luminescent and upconverting nanoparticle probes with long lifetimes that allow time-gated, background-free detection; hyperspectral unmixing of native cellular autofluorescence (NADH, FAD, porphyrins) as a completely label-free readout of cell state, which she has pushed toward clinical use in reproductive medicine and cancer; and nanoparticle-mediated therapy. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — time-gated luminescence and NV relaxometry are two solutions to the same problem — how to read a faint, specific signal out of an autofluorescent, optically hostile biological background — and her clinical translation experience is exactly the missing capability in most quantum-biosensing groups. Preferred attribute present: advanced/label-based imaging with a genuine human-application pathway.