Description: Detection and manipulation of nuclear spin polarization for structural biology, materials characterization, and quantum sensing.
Boskovic is a synthetic inorganic chemist working on lanthanoid and polyoxometalate molecular magnets, valence tautomeric and redox-switchable complexes, and the design of molecules whose spin states can be addressed and switched. The group's relevance to quantum sensing is that these are chemically tunable spin qubits: unlike solid-state defects, their coordination environment, nuclear-spin bath and anisotropy can be designed atom by atom, which is the argument for molecular qubits as sensors. Characterisation is by SQUID magnetometry, EPR and ab initio calculation. Positioned against the established body of NV-ensemble quantum sensing work โ DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity โ molecular spin qubits are the chemistry community's answer to the NV centre, and DEER/pulsed-EPR protocols developed for NV ensembles at pT/sqrt(Hz) transfer more or less directly to these systems. Borderline inclusion (synthesis-led rather than sensitivity-led), kept per the inclusive rubric.
Bowen leads the CQSE 'Spins and Qubits' theme at Manchester, focusing on organometallic molecular spin qubits for quantum sensing and computing. Research directions: (1) Organometallic La(II) and other rare-earth molecular qudits โ designing molecules with multiple accessible spin states (qudits) for encoding quantum information and sensing; (2) Pulsed EPR characterization โ Hahn echo, ESEEM, ENDOR at X/W/Q-band to measure coherence times and hyperfine couplings; (3) Integration of molecular qubits into devices โ surface deposition and nanoscale addressing; (4) Multi-spin sensing โ using exchange-coupled spin pairs as differential sensors of magnetic field gradients. Closely collaborates with Tuna and Winpenny.
Gardner's group develops infrared and Raman microspectroscopy for biomedical diagnostics and disease sensing. Research directions: (1) FTIR synchrotron microspectroscopy โ using Diamond Light Source synchrotron IR beam for high-spatial-resolution chemical mapping of biological tissues for cancer diagnosis; (2) Raman microspectroscopy โ label-free chemical imaging of cells and tissue for disease classification using machine-learning chemometrics; (3) SERS probes โ developing gold nanoparticle SERS labels for targeted cancer biomarker detection; (4) Breathomics โ on-chip photonic sensors for exhaled breath analysis for early disease detection. The infrared and Raman methods provide label-free molecular sensing with potential for quantum-enhanced sensitivity.
Gruetter leads the Laboratory for Functional and Metabolic Imaging (LFMI) at EPFL and co-directs the CIBM (Centre for Biomedical Imaging). Research directions: (1) Ultra-high-field in vivo MR spectroscopy โ developing 1H, 13C, 31P, 23Na MRS at 14.1T animal and 7T human systems to measure metabolite concentrations (glutamate, GABA, lactate) in brain with unprecedented sensitivity; (2) Quantum coherence effects in NMR โ exploiting J-coupling evolution and JPRESS sequences for quantum-selective metabolite editing; (3) Hyperpolarization โ DNP-enhanced metabolite sensing in vivo for tracking metabolic flux in real time; (4) Neuroimaging โ quantitative BOLD fMRI calibration and cerebral blood flow mapping. The 14.1T magnet is among the world's most powerful for biological NMR spectroscopy.
The Han Lab (Chemistry, joined fall 2023) develops quantum sensing tools rooted in electron and nuclear spin physics for life-science applications. Directions: (1) DNP-enhanced NMR quantum sensing using coupled electron-nuclear spin clusters โ designing novel biradical and multi-spin systems achieving 700-fold ยนยณC signal enhancement at 14.1 T via P1 center clusters in HPHT diamond (exchange coupling >100 MHz); aiming for in-cell NMR with sensitivity to track water dynamics in a single cell; (2) High-field pulsed EPR at 240 GHz / 8.6 T: time-resolved Gd-Gd EPR (TiGGER) for tracking inter-residue distances during protein functional cycles in solution with sub-nm resolution; rapid-scan field-domain EPR development; (3) Integration of DNP/EPR with nanodiamond-based quantum sensors: coupled electron-nuclear spin cluster design for long-range quantum sensing in biological environments, bridging conventional NMR/EPR and NV-center-based quantum sensing. Han directs the EPR/DNP component of IMSERC (Northwestern's core facility) and brought three new EPR spectrometers and a 600 MHz DNP-NMR system.
McInnes leads the National EPR Facility at Manchester (Europe's broadest EPR suite) and researches molecular spin qubits. Research directions: (1) Pulsed EPR spectroscopy of molecular spin systems โ Hahn echo, ESEEM, ENDOR, DEER for structural and electronic characterization of inorganic and organometallic complexes; (2) Molecular spin qubits โ [Cu(mnt)2]ยฒโป and related molecules as candidate qubits; measuring coherence times and investigating decoherence mechanisms; (3) Multi-qubit molecular registers โ using exchange interactions for two-qubit gates within a molecule; (4) Magnetic sensing applications โ molecular systems for magnetic field sensing below the diffraction limit. Partner of NPL M4Q EPSRC Network for Materials for Quantum.
Morello heads the Fundamental Quantum Technologies Laboratory and is the person who first read out the spin of a single electron, and then a single nucleus, in silicon. Current directions: high-spin donors (antimony-123, with eight nuclear levels) used as qudits and as sensors of local strain and electric field; nuclear acoustic resonance, in which a strain wave rather than a magnetic field drives the nuclear spin; engineered decoherence experiments as tests of quantum foundations; and precision tomography of multi-qubit donor registers. The group's donors are among the longest-coherence solid-state spins known (seconds for nuclei). Positioned against the established body of NV-ensemble quantum sensing work โ DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity โ a single-donor nuclear spin in silicon is functionally an NV centre with better coherence and worse readout: the same DEER, dynamical-decoupling and nuclear-register protocols apply, and the group's high-spin qudit work is aimed at exactly the multi-level sensing enhancements that the NV community is now chasing. Preferred attribute present: sensitivity and coherence, not fabrication, are the limiting variables here.
Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale โ custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering โ a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work โ DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity โ the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.
Winpenny holds the Regius Chair in Chemistry at Manchester and is a world leader in molecular magnetism and molecular nanomagnets for quantum technologies. Research directions: (1) Molecular nanomagnets โ synthesis of Cr7Ni 'horseshoe' rings and related cage clusters as prototype molecular qubits with long T2 times; (2) Multi-qubit molecular architectures โ covalently linked molecular qubit pairs and arrays for quantum gate operations and distributed sensing; (3) Quantum error correction in molecules โ designing molecular systems encoding logical qubits with error protection; (4) Quantum sensing applications โ molecular spin systems as ultra-sensitive nanoscale magnetic sensors in the sub-nm regime. Leading the NPL M4Q Network and UK molecular qubit community.