Marileen Dogterom (Full Professor, BioNanoscience) studies cytoskeleton dynamics and synthetic cell construction. Research: (1) microtubule dynamics — force generation, catastrophe control, and mitotic spindle assembly reconstituted in vitro; (2) cell division reconstitution — building minimal synthetic cells with controlled division; (3) optical tweezers and fluorescence microscopy for force measurement on single cytoskeletal elements. Co-founded BioNanoscience department.

Gijsje Koenderink (Full Professor, BioNanoscience) investigates active and passive mechanics of the cytoskeleton. Research: (1) active matter — motor-filament composite networks generating spontaneous mechanical activity; (2) cell mechanics — cytoskeletal contributions to cell shape, migration, and division; (3) biomaterials — designing synthetic cytoskeletal analogues; (4) optical tweezers and AFM rheology of reconstituted networks. Spinoza Prize 2021. ERC Advanced Grant.

Rock builds custom single-molecule fluorescence microscopes and optical tweezers to directly watch individual myosin motors move along the actin cytoskeleton in vitro and in living cells, quantifying motor stoichiometry, force generation, and navigation rules that organize cell shape and motility. Where NV-ensemble quantum sensors read out spin ensembles magnetically at pT/sqrt(Hz) sensitivity via DEER/NMR/T1 protocols, Rock's approach achieves single-fluorophore and single-motor mechanical/positional resolution using all-optical single-molecule methods.