Tags - (2) membrane biophysics thermodynamics nerve pulse

Techniques:
Department(s)/lab(s): Physics / Niels Bohr Institute | Membrane Biophysics Group (Heimburg) @ UCPH
Summary:

Thomas Heimburg (Professor, NBI Membranes group) works on thermodynamics and biophysics of biological membranes. Research: (1) theory of nerve pulse propagation as electromechanical solitons ('soliton model'); (2) lipid membrane phase transitions — calorimetry, DSC, AFM; (3) anesthesia mechanism via membrane phase perturbation; (4) ion-channel-like events in pure lipid membranes near phase transitions. Notably co-authored 2016 Scientific Reports paper with QUANTOP (Jensen et al.) demonstrating non-invasive detection of nerve impulses using atomic magnetometry — direct overlap with quantum sensing.

Department(s)/lab(s): Institute of Biomaterials and Biomolecular Systems | Nussberger Lab - Biophysics @ Stuttgart
Summary:

Nussberger holds the biophysics chair at Stuttgart's Institute of Biomaterials and Biomolecular Systems. The group studies how proteins cross and insert into membranes -- mitochondrial protein translocases (TOM complex), apoptosis-related pore formation -- using single-channel electrophysiology, single-molecule fluorescence and structural methods, and has pushed this into an explicit nanopore/biosensing line: engineered protein and DNA-based pores as single-molecule sensors, including the DNA-origami nanosyringe for directed membrane translocation published with Na Liu's group. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), the relevance is the readout channel: nanopore sensing is the electrical single-molecule counterpart to optical single-molecule detection, and the group's membrane expertise is exactly what an in-cell quantum-sensing project needs when the question becomes how to get the probe across a bilayer.