Technique - (1) Rotating Optical Coherence Scattering (ROCS) microscopy

Type: Experimental

Description: Label-free interferometric scattering microscopy using rotating illumination; achieves ~150 nm lateral, ~10 nm axial resolution for tracking intracellular dynamics in plant cells.

Department(s)/lab(s): Physics / Niels Bohr Institute | BendixLab — Biophotonics & Mechanobiology @ UCPH
Summary:

Poul Martin Bendix (Associate Professor, BendixLab/NBI) investigates physical properties of living cells using advanced optical techniques. Research: (1) optical tweezers for mechanosensing — GPCR mechanosensing with picoNewton force resolution, membrane curvature sensing by proteins (annexins, BAR-domain proteins); (2) thermoplasmonics — gold nanoparticle laser heating for controlled membrane microsurgery, cell fusion, and plasma membrane repair; (3) single-molecule biophysics — DNA-protein interactions using 4-trap optical tweezers (LUMICKS C-Trap) with STED imaging; (4) filopodia dynamics — twist and rotation of actin filaments; (5) Brillouin microscopy for cell mechanics; (6) COBM center management. GPCRmec consortium (Novo Nordisk). 2026 BPS Annual Meeting featured.