Technique - (2) SOFI super-resolution optical fluctuation imaging

Type: Experimental

Description: Camera-based super-resolution using temporal higher-order statistics of blinking fluorophore signals to resolve structures beyond the diffraction limit without switching control.

Kristin Grußmayer 🔗
Delft University of Technology 🔗
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Department(s)/lab(s): BioNanoscience / Kavli Institute of Nanoscience | Kristin Grußmayer Lab — Super-Resolution Microscopy @ TU Delft
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Kristin Grußmayer (Assistant Professor, BioNanoscience, 2021) develops super-resolution microscopy tools. Research: (1) SOFI (super-resolution optical fluctuation imaging) — camera-based super-resolution using photon statistics; (2) multi-plane super-resolution and quantitative phase imaging — combined modalities for 3D sub-diffraction imaging; (3) new fluorescence probe classes for SMLM; (4) AI-driven smart microscopy for automated phenotype detection. Marie Curie Fellow (EPFL, Lasser group). Group established 2021.

Philip Hemmer 🔗
Texas A&M University 🔗
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Department(s)/lab(s): Electrical & Computer Engineering | Hemmer Quantum Photonics Laboratory @ TAMU
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Hemmer pioneered NV-diamond spin sensing and super-resolution with spin defects, working on coherent control, photonic integration of NV sensors, and diamond-based magnetometry/imaging bridging physics and engineering. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is directly in the NV ensemble sensing lineage, emphasizing photonic integration and super-resolution readout.