Research Areas - (227) Biophysics

Full path: Biology > Biophysics

Department(s)/lab(s): School of Chemistry | Gooding Biosensors and Surface Chemistry Group @ UNSW
Summary:

Gooding is one of the world's most-cited biosensor scientists (inaugural editor-in-chief of ACS Sensors) and runs a group of over thirty researchers spanning surface chemistry, electrochemistry and nanomedicine. The sensing programme that matters here is the move from ensemble to digital, single-molecule-resolved detection: nanoparticle-tethered electrochemical sensors in which single binding events are counted rather than averaged, nanopore blockade sensors for protein biomarkers such as PSA, amplification-free nucleic-acid detection, and antifouling surface chemistries that make any of this work in real biological fluid. He has a strong commercialisation record (AgaMatrix glucose sensors). Positioned against the established body of NV-ensemble quantum sensing work β€” DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β€” his single-molecule-counting philosophy is the biosensing analogue of moving from a pT/sqrt(Hz) NV ensemble to single-spin detection: in both cases the sensitivity gain comes from resolving individual events rather than improving an averaged signal. He is also the obvious collaborator for anyone trying to functionalise a diamond or nanoparticle quantum sensor for a real analyte.

Department(s)/lab(s): Electrical, Computer & Energy Engineering | Gopinath Lab @ CUBoulder
Summary:

Gopinath's group develops photonic tools for sensing and imaging - electrowetting adaptive-optics and miniature two-photon/STED microscopes for in vivo neural imaging, dual-comb ranging and orbital-angular-momentum rotation sensing, and mid-infrared lasers/materials and fiber sensing. For context, this complements the established paradigm of NV-diamond ensemble magnetometry (Hahn-echo/DEER, nanoscale NMR, T1 relaxometry) operating near pT/√Hz sensitivity.

Department(s)/lab(s): Biology and Biological Engineering | Gradinaru Lab (CLOVER Center) @ Caltech
Summary:

Gradinaru's group develops neurotechnologies - tissue clearing (CLARITY/PACT), engineered AAV gene-delivery vectors that cross the blood-brain barrier, optogenetic actuators/sensors, and light-sheet + single-molecule FISH imaging of cleared tissue - to map and manipulate neural circuits underlying neurodegeneration and behavior. For context, this complements the established paradigm of NV-diamond ensemble magnetometry (Hahn-echo/DEER, nanoscale NMR, T1 relaxometry) operating near pT/√Hz sensitivity.

Department(s)/lab(s): Physics & Astronomy – Photon Science Institute | Graham Group (SERS and Nanoplasmonic Biosensing) @ Manchester
Summary:

Graham's group develops SERS-based nanoplasmonic sensing platforms for biomedical applications. Research directions: (1) SERS nanogap substrates β€” engineering colloidal gold and silver nanostructure clusters with reproducible, high-enhancement nanogaps for single-molecule SERS detection; (2) In vivo SERS β€” intravenous SERS nanotags for tumor imaging and multiplexed biomarker detection in living organisms; (3) Microfluidic SERS β€” integrating SERS probes in microfluidic channels for continuous monitoring of circulating biomarkers; (4) Quantitative SERS β€” calibration strategies for absolute analyte quantification for clinical diagnostics. Extreme sensitivity (single-molecule) relevant to quantum-enhanced optical sensing.

Department(s)/lab(s): Physics – Institute for Quantum Electronics | Optical Nanomaterial Group (Grange) @ ETH Zurich
Summary:

Grange leads the Optical Nanomaterial Group at ETH, developing nonlinear materials for quantum photonic integrated circuits. Research directions: (1) Barium titanate (BTO) nanophotonics β€” scalable CMOS-compatible BTO thin-film integrated circuits exploiting large Ο‡(2) nonlinearity for quantum entangled photon-pair generation via SPDC; (2) Lithium niobate on insulator (LNOI) β€” quantum photonic integrated circuits for heralded single-photon sources and electro-optic transduction; (3) Second-harmonic generation sensing β€” SHG-active nanocrystals as contrast agents and phase-sensitive probes in biological imaging; (4) On-chip entangled photon sources for quantum communication and sensing. Strong quantum sensing application in nonlinear optical readout of quantum states.

Department(s)/lab(s): Physics | Laboratory for the Physics of Life @ Princeton
Summary:

Gregor's Laboratory for the Physics of Life builds custom quantitative microscopes (single-objective oblique-plane light-sheet, multicolor live-imaging, single-molecule transcription imaging) to make precision, physics-style measurements of gene expression, morphogen gradients, and chromatin dynamics in living Drosophila embryos and mammalian gastruloids. He is actively recruiting PhD students and postdocs with expertise in super-resolution imaging, nonlinear/ultrafast optics, and instrumentation development.

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Department(s)/lab(s): Physics (LKB) | Polarised Helium, Quantum Fluids and Solids Team @ ENS Paris
Summary:

Grucker works on optically-pumped, spin-exchange hyperpolarized helium-3 for quantum-fluid physics and biomedical MRI contrast, part of LKB's polarized-helium team that historically bridges fundamental AMO physics with clinical lung-imaging applications.

Department(s)/lab(s): Physics – Institute of Physics (IPHYS) / CIBM | Laboratory for Functional and Metabolic Imaging (Gruetter Group, CIBM) @ EPFL
Summary:

Gruetter leads the Laboratory for Functional and Metabolic Imaging (LFMI) at EPFL and co-directs the CIBM (Centre for Biomedical Imaging). Research directions: (1) Ultra-high-field in vivo MR spectroscopy β€” developing 1H, 13C, 31P, 23Na MRS at 14.1T animal and 7T human systems to measure metabolite concentrations (glutamate, GABA, lactate) in brain with unprecedented sensitivity; (2) Quantum coherence effects in NMR β€” exploiting J-coupling evolution and JPRESS sequences for quantum-selective metabolite editing; (3) Hyperpolarization β€” DNP-enhanced metabolite sensing in vivo for tracking metabolic flux in real time; (4) Neuroimaging β€” quantitative BOLD fMRI calibration and cerebral blood flow mapping. The 14.1T magnet is among the world's most powerful for biological NMR spectroscopy.

Department(s)/lab(s): BioNanoscience / Kavli Institute of Nanoscience | Kristin Grußmayer Lab β€” Super-Resolution Microscopy @ TU Delft
Summary:

Kristin Grußmayer (Assistant Professor, BioNanoscience, 2021) develops super-resolution microscopy tools. Research: (1) SOFI (super-resolution optical fluctuation imaging) β€” camera-based super-resolution using photon statistics; (2) multi-plane super-resolution and quantitative phase imaging β€” combined modalities for 3D sub-diffraction imaging; (3) new fluorescence probe classes for SMLM; (4) AI-driven smart microscopy for automated phenotype detection. Marie Curie Fellow (EPFL, Lasser group). Group established 2021.

Department(s)/lab(s): Physics (Biological Physics) | Chromatin Dynamics Lab @ Oxford
Summary:

Gruszka's Chromatin Dynamics Lab combines real-time single-molecule imaging with biochemistry and biophysics (including in Xenopus egg-extract systems) to study how epigenetic information carried by nucleosomes is disassembled and re-established during DNA replication. The lab is actively recruiting postdoctoral fellows.