Gooding is one of the world's most-cited biosensor scientists (inaugural editor-in-chief of ACS Sensors) and runs a group of over thirty researchers spanning surface chemistry, electrochemistry and nanomedicine. The sensing programme that matters here is the move from ensemble to digital, single-molecule-resolved detection: nanoparticle-tethered electrochemical sensors in which single binding events are counted rather than averaged, nanopore blockade sensors for protein biomarkers such as PSA, amplification-free nucleic-acid detection, and antifouling surface chemistries that make any of this work in real biological fluid. He has a strong commercialisation record (AgaMatrix glucose sensors). Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β his single-molecule-counting philosophy is the biosensing analogue of moving from a pT/sqrt(Hz) NV ensemble to single-spin detection: in both cases the sensitivity gain comes from resolving individual events rather than improving an averaged signal. He is also the obvious collaborator for anyone trying to functionalise a diamond or nanoparticle quantum sensor for a real analyte.
Gopinath's group develops photonic tools for sensing and imaging - electrowetting adaptive-optics and miniature two-photon/STED microscopes for in vivo neural imaging, dual-comb ranging and orbital-angular-momentum rotation sensing, and mid-infrared lasers/materials and fiber sensing. For context, this complements the established paradigm of NV-diamond ensemble magnetometry (Hahn-echo/DEER, nanoscale NMR, T1 relaxometry) operating near pT/βHz sensitivity.
Gradinaru's group develops neurotechnologies - tissue clearing (CLARITY/PACT), engineered AAV gene-delivery vectors that cross the blood-brain barrier, optogenetic actuators/sensors, and light-sheet + single-molecule FISH imaging of cleared tissue - to map and manipulate neural circuits underlying neurodegeneration and behavior. For context, this complements the established paradigm of NV-diamond ensemble magnetometry (Hahn-echo/DEER, nanoscale NMR, T1 relaxometry) operating near pT/βHz sensitivity.
Graham's group develops SERS-based nanoplasmonic sensing platforms for biomedical applications. Research directions: (1) SERS nanogap substrates β engineering colloidal gold and silver nanostructure clusters with reproducible, high-enhancement nanogaps for single-molecule SERS detection; (2) In vivo SERS β intravenous SERS nanotags for tumor imaging and multiplexed biomarker detection in living organisms; (3) Microfluidic SERS β integrating SERS probes in microfluidic channels for continuous monitoring of circulating biomarkers; (4) Quantitative SERS β calibration strategies for absolute analyte quantification for clinical diagnostics. Extreme sensitivity (single-molecule) relevant to quantum-enhanced optical sensing.
Grange leads the Optical Nanomaterial Group at ETH, developing nonlinear materials for quantum photonic integrated circuits. Research directions: (1) Barium titanate (BTO) nanophotonics β scalable CMOS-compatible BTO thin-film integrated circuits exploiting large Ο(2) nonlinearity for quantum entangled photon-pair generation via SPDC; (2) Lithium niobate on insulator (LNOI) β quantum photonic integrated circuits for heralded single-photon sources and electro-optic transduction; (3) Second-harmonic generation sensing β SHG-active nanocrystals as contrast agents and phase-sensitive probes in biological imaging; (4) On-chip entangled photon sources for quantum communication and sensing. Strong quantum sensing application in nonlinear optical readout of quantum states.
Gregor's Laboratory for the Physics of Life builds custom quantitative microscopes (single-objective oblique-plane light-sheet, multicolor live-imaging, single-molecule transcription imaging) to make precision, physics-style measurements of gene expression, morphogen gradients, and chromatin dynamics in living Drosophila embryos and mammalian gastruloids. He is actively recruiting PhD students and postdocs with expertise in super-resolution imaging, nonlinear/ultrafast optics, and instrumentation development.
Grucker works on optically-pumped, spin-exchange hyperpolarized helium-3 for quantum-fluid physics and biomedical MRI contrast, part of LKB's polarized-helium team that historically bridges fundamental AMO physics with clinical lung-imaging applications.
Gruetter leads the Laboratory for Functional and Metabolic Imaging (LFMI) at EPFL and co-directs the CIBM (Centre for Biomedical Imaging). Research directions: (1) Ultra-high-field in vivo MR spectroscopy β developing 1H, 13C, 31P, 23Na MRS at 14.1T animal and 7T human systems to measure metabolite concentrations (glutamate, GABA, lactate) in brain with unprecedented sensitivity; (2) Quantum coherence effects in NMR β exploiting J-coupling evolution and JPRESS sequences for quantum-selective metabolite editing; (3) Hyperpolarization β DNP-enhanced metabolite sensing in vivo for tracking metabolic flux in real time; (4) Neuroimaging β quantitative BOLD fMRI calibration and cerebral blood flow mapping. The 14.1T magnet is among the world's most powerful for biological NMR spectroscopy.
Kristin GruΓmayer (Assistant Professor, BioNanoscience, 2021) develops super-resolution microscopy tools. Research: (1) SOFI (super-resolution optical fluctuation imaging) β camera-based super-resolution using photon statistics; (2) multi-plane super-resolution and quantitative phase imaging β combined modalities for 3D sub-diffraction imaging; (3) new fluorescence probe classes for SMLM; (4) AI-driven smart microscopy for automated phenotype detection. Marie Curie Fellow (EPFL, Lasser group). Group established 2021.
Gruszka's Chromatin Dynamics Lab combines real-time single-molecule imaging with biochemistry and biophysics (including in Xenopus egg-extract systems) to study how epigenetic information carried by nucleosomes is disassembled and re-established during DNA replication. The lab is actively recruiting postdoctoral fellows.