Booth's Dynamic Optics and Photonics Group develops adaptive-optics methods (deformable mirrors, spatial light modulators) for aberration correction in confocal, two-photon and super-resolution (STORM/STED/SIM) microscopy, enabling higher-fidelity deep-tissue biomedical imaging, alongside applications in ultrafast laser micro-fabrication of photonic devices.

Defienne leads the Quantum Imaging Paris group at INSP, using spatial correlations and Hong-Ou-Mandel-type interference between entangled photon pairs to build microscopes that see through scattering media and correct optical aberrations without a spatial light modulator. His ERC-funded CORAMI project develops correlation-based adaptive optics as a universal add-on module for existing microscopes, targeting deeper (>1 mm), higher-contrast in-vivo imaging for neuroscientists, dermatologists, and ophthalmologists.

Paterson develops adaptive-optics and wavefront-sensing techniques to correct optical aberrations in fluorescence microscopy and imaging through complex/turbid media, improving resolution and depth in biological and biomedical imaging.

Upadhyayula (trained with Eric Betzig at Janelia) develops multifunctional adaptive-optical super-resolution microscopy and the large-scale computational pipelines needed to reconstruct terabyte- to petabyte-scale 3D subcellular dynamics datasets. The group is actively recruiting postdocs.