Research Areas - (8) Magnetic Nanoparticle Biosensing and Theranostics

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Magnetic Nanoparticle Biosensing and Theranostics

Department(s)/lab(s): Materials Science and Engineering | Anikeeva Lab (Bioelectronics Group) @ MIT
Summary:

PREFERRED. Anikeeva's Bioelectronics Group engineers minimally invasive, multifunctional fiber-based neural probes (combining optical, electrical, and microfluidic channels) and magnetic nanoparticle transducers that enable wireless, gene- and wire-free magnetothermal, magnetomechanical, and chemomagnetic neuromodulation, with applications spanning deep-brain stimulation and gut-brain circuit interrogation.

Department(s)/lab(s): Bioengineering and Electrical Engineering & Computer Sciences | Conolly Berkeley Imaging Systems Lab @ UCB
Summary:

Conolly builds Magnetic Particle Imaging (MPI) scanners, a tracer-based imaging modality that detects the nonlinear magnetization response of superparamagnetic nanoparticles with high sensitivity, safety, and zero background signal from tissue, alongside compressed-sensing MRI methods.

Department(s)/lab(s): Physics & Astronomy – Biophysics | Jones Lab (Optical Tweezers Biophysics) @ UCL
Summary:

Jones's group develops optical tweezers instrumentation for biological applications. Research directions: (1) Single-cell mechanics — using optical traps to apply calibrated forces to cells and measure viscoelastic properties relevant to cancer invasion and immune response; (2) Motor protein biophysics — measuring force-velocity curves of kinesin/myosin motors at the single-molecule level; (3) Optical sorting — holographic optical tweezers for cell sorting by mechanical phenotype; (4) Instrument development — fast-switching AOD-based traps, quantitative phase imaging combined with force measurement. Sensitive to pN forces, combining biosensing with fundamental biophysics.

Department(s)/lab(s): School of Physics / Institute of Medical Physics | Kuncic Medical Physics and Nanoscale Systems Group @ USyd
Summary:

Kuncic works across medical physics and nanoscale systems: nanoparticle-enhanced radiotherapy and dosimetry (where high-Z nanoparticles act as local dose amplifiers and the physics question is energy deposition at nanometre scales), nanoparticle contrast agents and theranostics, and — separately — neuromorphic nanowire networks as physical computing substrates. The medical-physics thread is the relevant one here: it is about quantifying and imaging what a nanoscale probe does inside tissue. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the nanoparticle-in-tissue problem she works on is the same delivery-and-quantification problem that determines whether an in-cell nanodiamond sensor operating near the pT/sqrt(Hz) regime reports anything biologically meaningful. Borderline inclusion; a candidate would be bringing quantum sensing to her, not the reverse.

Department(s)/lab(s): Medical Physics and Biomedical Engineering | UCL Healthcare Biomagnetics Laboratory @ UCL
Summary:

Pankhurst directs the UCL Healthcare Biomagnetics Laboratory, developing magnetic nanoparticles and instrumentation for clinical use: AC-susceptometry-based sentinel-lymph-node localization for breast cancer surgical staging (commercialized as Endomag), magnetic particle imaging, and magnetic hyperthermia therapy. He is a participant in the Q-BIOMED quantum-biomedical-sensing hub, connecting magnetic biosensing with the hub's broader quantum-diagnostics translation effort.

Department(s)/lab(s): School of Physics | Quantum Nanoscience Laboratory @ USyd
Summary:

Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale — custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering — a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.

Department(s)/lab(s): School of Chemistry | Tilley Nanomaterials and Electron Microscopy Group @ UNSW
Summary:

Tilley directs the UNSW Electron Microscope Unit and runs a nanomaterials group whose distinctive capability is in-situ liquid-cell TEM: watching nanoparticle nucleation, growth and catalytic transformation in real time inside the microscope, in liquid, rather than inferring mechanism from before-and-after snapshots. The synthetic side produces magnetic and plasmonic nanoparticles used as biosensor labels and MRI contrast agents, largely in collaboration with Gooding and Reece. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the group is a supplier and characteriser of the nanoparticle probes that in-cell quantum sensing depends on — including the magnetic-nanoparticle labels whose stray fields a pT/sqrt(Hz) NV sensor would actually detect — and the liquid-cell TEM capability is a rare way to validate what those particles are doing in situ. Borderline inclusion (materials characterisation rather than sensing), kept for the collaborative infrastructure it represents.

Department(s)/lab(s): Electrical Engineering | Wang Lab (Spintronics/Biomagnetics) @ Stanford
Summary:

Wang develops giant-magnetoresistance (GMR) spin-valve biosensor chips that detect magnetic-nanoparticle-tagged biomolecules with high sensitivity and multiplexing for protein and nucleic-acid diagnostics -- a solid-state magnetic-sensing approach to biosensing that sits alongside NV-ensemble and OPM-based approaches at a very different sensitivity/format tradeoff.