Description: Scanning single-point fluorescence collection for single-NV or single-molecule readout.
Ananthanarayanan was awarded the Royal Microscopical Society Life Sciences Award in 2025 for the use of novel microscopies in cell biology. Her group images individual motor proteins β dynein, kinesin β and the mitochondria they transport, in living cells, at single-molecule sensitivity, combining light-sheet and TIRF-class imaging with particle tracking to ask how organelle positioning and mitochondrial dynamics are controlled. The methodological emphasis is on getting single-molecule sensitivity inside a live cell rather than in vitro, which is the hard version of the problem. Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β this is the closest thing at UNSW to a biological end-user for an in-cell quantum sensor: the mitochondrial systems she studies are precisely where NV nanodiamond thermometry and free-radical relaxometry at pT/sqrt(Hz) have been aimed, and she has the live-cell imaging infrastructure to validate any such measurement independently.
AtatΓΌre leads the ~30-person QOMS group at the Cavendish. Three main thrusts: (1) Spin-based quantum networks β demonstrating distant entanglement generation and photonic cluster states using semiconductor quantum dots (InGaAs, GaAs) and diamond spin defects (NV, SiV, SnV), including a many-body nuclear-spin quantum register demonstrated in 2025 (Nature Physics); (2) Quantum-enhanced nanoscale sensing β scanning NV diamond magnetometry of emergent magnetism in novel 2D/layered materials and quantum transport in nanocircuits, plus nanodiamond-based in-cell sensing (nanoMRI, thermometry, diffusion in C. elegans); (3) Novel quantum materials β hexagonal boron nitride (hBN) optically-active spin defects at room temperature, and moirΓ© physics in TMD heterostructures. He is co-founder and CSO of Nu Quantum Ltd.
Research focuses on quantum dynamics and excited-state reactivity in biological and synthetic light-harvesting systems. Discovered long-lived quantum coherence in photosynthetic light-harvesting complexes (FMO, 2007). Develops 2D electronic spectroscopy techniques to probe excitonic transport, open quantum systems, and photochemical reaction dynamics on femtosecond timescales. Director NSF QuBBE; co-director Berggren Center for Quantum Biology and Medicine.
Gambin was the first EMBL Australia group leader appointed to Single Molecule Science. His signature method combines cell-free protein expression with two-colour single-molecule coincidence and fluctuation spectroscopy, which sidesteps purification entirely: proteins are expressed, labelled and measured in lysate, an order of magnitude faster than conventional interaction assays. The biology is protein self-association and aggregation β alpha-synuclein in Parkinson's, cardiac and muscular disease proteins β where the size distribution of oligomers, not the mean, is the quantity of interest. Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β the conceptual overlap with quantum biosensing is the insistence on distributions over averages, and his aggregation systems (paramagnetic-species-generating, redox-active amyloid) are a plausible target for T1-relaxometry-based NV detection at pT/sqrt(Hz) in the near term.
Gigan leads the Optical Imaging group at LKB, pioneering wavefront shaping and computational imaging through scattering media. Research directions: (1) Wavefront shaping / transmission matrix β measuring the ~10^5 optical modes of a scattering sample's transmission matrix to focus and image through highly scattering biological tissues; roadmap on deep tissue imaging (J. Phys. Photonics 2022, lead author); (2) Multimode quantum optics through complex media β spatially multimode squeezed states transmitted through scattering media for quantum-enhanced imaging; (3) Optical computing / AI β using multiple scattering as a physical neural network for reservoir computing and nonlinear machine learning (LightOn spin-off, 2016); (4) Neurophotonics applications β focusing through the skull for deep brain imaging. Two ERC grants (2011, 2017). Optica Fellow. IUF member (2016β2021).
Goldys was Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics and now leads a nanoscale biophotonics group in Biomedical Engineering. The programme is about extracting diagnostic information from very weak optical signals inside cells and tissue: luminescent and upconverting nanoparticle probes with long lifetimes that allow time-gated, background-free detection; hyperspectral unmixing of native cellular autofluorescence (NADH, FAD, porphyrins) as a completely label-free readout of cell state, which she has pushed toward clinical use in reproductive medicine and cancer; and nanoparticle-mediated therapy. Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β time-gated luminescence and NV relaxometry are two solutions to the same problem β how to read a faint, specific signal out of an autofluorescent, optically hostile biological background β and her clinical translation experience is exactly the missing capability in most quantum-biosensing groups. Preferred attribute present: advanced/label-based imaging with a genuine human-application pathway.
Studies optical quantum science in solid-state systems with emphasis on photonic integration. Directions: (1) photonic integration of NV-center spin qubits in diamond nanophotonic circuits for scalable quantum sensing arrays; (2) 2D semiconductor (TMD) nanophotonic devices exploiting valley and spin-valley degrees of freedom; (3) engineering light-matter interactions for quantum information and sensing in nanoscale optical cavities. Key goal: scalable on-chip quantum sensing platforms.
Hinde is a fluorescence-fluctuation physicist embedded in cell biology: she uses pair-correlation function analysis, number-and-brightness, phasor-FLIM and FRET to read out chromatin compaction, protein-chromatin binding dynamics and nucleocytoplasmic transport in living nuclei, at spatial and temporal scales that conventional imaging averages away. The programme is a technique-pushing one β the emphasis is on extracting nanoscale structural information from photon statistics rather than on brute-force localisation β and it is now being coupled to quantum sensing through her QUBIC investigatorship, where the goal is to combine fluorescence readouts with NV-based magnetic and spin-noise contrast in the same cell. Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β her role in QUBIC is to supply the cell-biological questions and the correlative optical readouts that make pT/sqrt(Hz)-class ensemble sensing biologically interpretable. Preferred attribute present: lifetime- and orientation-resolved methods pushing past the usual resolution limits.
Hollenberg is the intellectual centre of gravity for diamond quantum sensing in Australia: a theorist-turned-programme-leader whose group develops NV-based quantum probes for biological systems and quantum-computing architectures in silicon and diamond. Current directions include the quantum-probe hyperspectral microscope, in which NV ensembles in a bulk diamond substrate report magnetic and spin-noise contrast from cells cultured directly on the surface; nanodiamond quantum probes for intracellular relaxometry and free-radical detection; theory of decoherence-based sensing (T1 relaxometry as a chemical-specificity channel rather than a nuisance); and single-cell magnetic resonance. He co-leads the Melbourne node of the ARC Centre of Excellence in Quantum Biotechnology (QUBIC) with Simpson and Hinde, which is explicitly chartered to build quantum sensors for live biology, including portable brain imagers. Positioned against the established body of NV-ensemble quantum sensing work β DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β his programme is one of the small number worldwide that has carried those ensemble protocols all the way into cell culture and tissue rather than stopping at proof-of-principle magnetometry. Preferred attribute present: the group's emphasis is on sensitivity and biological specificity rather than device fabrication, and QUBIC funding runs to 2030 with recurring postdoc recruitment.
Jacob Hoogenboom develops integrated correlative light and electron microscopy (CLEM) and molecular nanophotonic imaging. Research: (1) 3-in-1 microscopy combining light, electron beam, and ion beam for precise biological sample sectioning and protein localisation; (2) integrated CLEM for mapping proteins in cellular context; (3) single-molecule nanophotonic sensing using fluorescence. Relevant to advanced single-molecule biosensing approaches.