Jacob Hoogenboom develops integrated correlative light and electron microscopy (CLEM) and molecular nanophotonic imaging. Research: (1) 3-in-1 microscopy combining light, electron beam, and ion beam for precise biological sample sectioning and protein localisation; (2) integrated CLEM for mapping proteins in cellular context; (3) single-molecule nanophotonic sensing using fluorescence. Relevant to advanced single-molecule biosensing approaches.