Gardner's group develops infrared and Raman microspectroscopy for biomedical diagnostics and disease sensing. Research directions: (1) FTIR synchrotron microspectroscopy — using Diamond Light Source synchrotron IR beam for high-spatial-resolution chemical mapping of biological tissues for cancer diagnosis; (2) Raman microspectroscopy — label-free chemical imaging of cells and tissue for disease classification using machine-learning chemometrics; (3) SERS probes — developing gold nanoparticle SERS labels for targeted cancer biomarker detection; (4) Breathomics — on-chip photonic sensors for exhaled breath analysis for early disease detection. The infrared and Raman methods provide label-free molecular sensing with potential for quantum-enhanced sensitivity.
Garner uses high-resolution, single-molecule tracking and localization microscopy (PALM-based) to study the dynamic spatial organization of the bacterial cytoskeleton and cell-wall synthesis machinery in live prokaryotic cells at nanometer precision.
Garrido is a computational cognitive neuroscientist — predictive coding, Bayesian brain models, neuroimaging biomarkers for mental health — who was appointed a chief investigator of the ARC Centre of Excellence in Quantum Biotechnology specifically to work with the Melbourne and UQ physics groups on non-invasive quantum-sensor recording of human brain magnetic fields. She is the human-subject and source-reconstruction end of the QUBIC portable-brain-imager programme: her lab supplies the paradigms, the clinical cohorts and the inverse-problem modelling that a diamond- or OPM-based MEG system has to serve. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — she is not a sensor developer, but she is the reason the pT/sqrt(Hz)-class magnetometers being built at Melbourne have a human-trials pathway at all. Preferred attributes present in strength: bioelectromagnetism and human trials with novel quantum technologies. Included as a deliberate borderline case — a sensing postdoc would be the physics half of a collaboration with this lab, not a member of it.
Hylkje Geertsema uses single-molecule super-resolution fluorescence microscopy (TIRF, SMLM, PALM/STORM) to study DNA replication dynamics. Her lab visualises and quantifies individual replication proteins at replication forks in living cells to understand the kinetics and fidelity of DNA copying. Research focuses on measuring spatiotemporal dynamics of protein assemblies during DNA metabolism with nanometre resolution.
Gigan leads the Optical Imaging group at LKB, pioneering wavefront shaping and computational imaging through scattering media. Research directions: (1) Wavefront shaping / transmission matrix — measuring the ~10^5 optical modes of a scattering sample's transmission matrix to focus and image through highly scattering biological tissues; roadmap on deep tissue imaging (J. Phys. Photonics 2022, lead author); (2) Multimode quantum optics through complex media — spatially multimode squeezed states transmitted through scattering media for quantum-enhanced imaging; (3) Optical computing / AI — using multiple scattering as a physical neural network for reservoir computing and nonlinear machine learning (LightOn spin-off, 2016); (4) Neurophotonics applications — focusing through the skull for deep brain imaging. Two ERC grants (2011, 2017). Optica Fellow. IUF member (2016–2021).
Sylvain Gigan's PICO (Photonics, Information, and Complexity) group focuses on imaging through and with complex and scattering media. Research: (1) wavefront shaping through scattering media — adaptive optics and transmission matrix approaches for deep-tissue fluorescence imaging; (2) multimode quantum optics through complex media — pushing quantum light through scattering and multi-mode fibres; (3) analogue computing with random optical scattering media. Key for biosensing: deep tissue imaging at high spatial resolution and quantum-enhanced light manipulation.
Uses X-ray photoemission electron microscopy (X-PEEM) with XANES spectroscopy at synchrotron light sources to map crystal orientation and amorphous-to-crystalline transitions at ~10 nm resolution in biominerals (coral skeletons, sea urchin spines, mollusk nacre, tooth enamel).
Uses single-molecule fluorescence microscopy in live bacteria to study stochastic gene expression, chromosome organization, and cell-to-cell variability.
Goldys was Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics and now leads a nanoscale biophotonics group in Biomedical Engineering. The programme is about extracting diagnostic information from very weak optical signals inside cells and tissue: luminescent and upconverting nanoparticle probes with long lifetimes that allow time-gated, background-free detection; hyperspectral unmixing of native cellular autofluorescence (NADH, FAD, porphyrins) as a completely label-free readout of cell state, which she has pushed toward clinical use in reproductive medicine and cancer; and nanoparticle-mediated therapy. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — time-gated luminescence and NV relaxometry are two solutions to the same problem — how to read a faint, specific signal out of an autofluorescent, optically hostile biological background — and her clinical translation experience is exactly the missing capability in most quantum-biosensing groups. Preferred attribute present: advanced/label-based imaging with a genuine human-application pathway.
Gooding is one of the world's most-cited biosensor scientists (inaugural editor-in-chief of ACS Sensors) and runs a group of over thirty researchers spanning surface chemistry, electrochemistry and nanomedicine. The sensing programme that matters here is the move from ensemble to digital, single-molecule-resolved detection: nanoparticle-tethered electrochemical sensors in which single binding events are counted rather than averaged, nanopore blockade sensors for protein biomarkers such as PSA, amplification-free nucleic-acid detection, and antifouling surface chemistries that make any of this work in real biological fluid. He has a strong commercialisation record (AgaMatrix glucose sensors). Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — his single-molecule-counting philosophy is the biosensing analogue of moving from a pT/sqrt(Hz) NV ensemble to single-spin detection: in both cases the sensitivity gain comes from resolving individual events rather than improving an averaged signal. He is also the obvious collaborator for anyone trying to functionalise a diamond or nanoparticle quantum sensor for a real analyte.