Hinde is a fluorescence-fluctuation physicist embedded in cell biology: she uses pair-correlation function analysis, number-and-brightness, phasor-FLIM and FRET to read out chromatin compaction, protein-chromatin binding dynamics and nucleocytoplasmic transport in living nuclei, at spatial and temporal scales that conventional imaging averages away. The programme is a technique-pushing one — the emphasis is on extracting nanoscale structural information from photon statistics rather than on brute-force localisation — and it is now being coupled to quantum sensing through her QUBIC investigatorship, where the goal is to combine fluorescence readouts with NV-based magnetic and spin-noise contrast in the same cell. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — her role in QUBIC is to supply the cell-biological questions and the correlative optical readouts that make pT/sqrt(Hz)-class ensemble sensing biologically interpretable. Preferred attribute present: lifetime- and orientation-resolved methods pushing past the usual resolution limits.
Hoogenboom leads a biophysics group at UCL specializing in high-speed atomic force microscopy. Research directions: (1) High-speed AFM — imaging conformational dynamics of DNA, proteins (including membrane channels), and chromatin at ms time resolution and sub-nm spatial resolution in aqueous conditions; (2) Nuclear pore complex — mapping transport selectivity and structure of NPCs in native nuclear envelopes using AFM; (3) Antimicrobial mechanisms — imaging membrane disruption by antimicrobial peptides in real time; (4) AFM-based force spectroscopy — measuring single-molecule interaction forces in chromatin and protein assemblies. Strong relevance to biological sensing at the single-molecule level.
Jones's group develops optical tweezers instrumentation for biological applications. Research directions: (1) Single-cell mechanics — using optical traps to apply calibrated forces to cells and measure viscoelastic properties relevant to cancer invasion and immune response; (2) Motor protein biophysics — measuring force-velocity curves of kinesin/myosin motors at the single-molecule level; (3) Optical sorting — holographic optical tweezers for cell sorting by mechanical phenotype; (4) Instrument development — fast-switching AOD-based traps, quantitative phase imaging combined with force measurement. Sensitive to pN forces, combining biosensing with fundamental biophysics.
Prof. Kozorovitskiy (Neurobiology) studies neuromodulation and plasticity in the striatum and basal ganglia, with a distinctive emphasis on developing and applying advanced optical imaging methods. Imaging technique innovations: (1) Oblique plane illumination (OPI / scanned oblique plane illumination, SOPi) microscopy — a single-objective light-sheet technique achieving tilt-invariant volumetric imaging for rapid 3D capture of fluorescently labeled neural structures without mechanical tilting; (2) Two-photon fluorescence imaging and two-photon glutamate/neuromodulator photorelease for single-synapse resolution in live tissue; (3) Near-infrared genetically-encoded calcium indicators (with Verkhusha group) for in vivo multi-color neural recording with reduced photobleaching. The lab's technical contributions are centered on extending the spatial and volumetric resolution of live-tissue fluorescence imaging. Irving M. Klotz Research Professor of Neurobiology; Beckman Young Investigator 2015.
Designs programmable DNA nanodevices as quantitative fluorescent reporters to map second messengers in real time inside specific organelles of living cells. Research directions: (1) DNA origami ion-sensing nanodevices for pH, Cl-, Ca2+, HOCl, and membrane voltage with single-organelle addressability; (2) targeting nanodevices to endosomes, lysosomes, mitochondria, and ER to dissect organelle biology and disease mechanisms; (3) in vivo deployment in C. elegans and Drosophila. NIH Director's Pioneer Award 2022.
Kuncic works across medical physics and nanoscale systems: nanoparticle-enhanced radiotherapy and dosimetry (where high-Z nanoparticles act as local dose amplifiers and the physics question is energy deposition at nanometre scales), nanoparticle contrast agents and theranostics, and — separately — neuromorphic nanowire networks as physical computing substrates. The medical-physics thread is the relevant one here: it is about quantifying and imaging what a nanoscale probe does inside tissue. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the nanoparticle-in-tissue problem she works on is the same delivery-and-quantification problem that determines whether an in-cell nanodiamond sensor operating near the pT/sqrt(Hz) regime reports anything biologically meaningful. Borderline inclusion; a candidate would be bringing quantum sensing to her, not the reverse.
Lemke holds the chair of Synthetic Biophysics at JGU and is adjunct director at the Institute of Molecular Biology. The group's signature is combining genetic code expansion -- installing non-canonical amino acids so a dye can be clicked onto one chosen residue -- with single-molecule fluorescence: smFRET on intrinsically disordered proteins, super-resolution imaging of the nuclear pore complex and its FG-nucleoporin permeability barrier, and engineered membraneless organelles used as designer compartments in living cells. The result is single-molecule-resolution measurement of conformational dynamics and phase behaviour inside cells rather than in vitro. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), this is the strongest biosensing/advanced-microscopy host in Mainz: the labelling chemistry is precisely what a quantum-sensing postdoc would need to attach nanodiamonds or spin labels to a defined protein site, and the group already operates at the single-molecule sensitivity limit optically. Large, well-funded, internationally recruiting group.
Liu's group sits at the junction of DNA nanotechnology and nanophotonics: DNA-origami-templated plasmonic assemblies, reconfigurable artificial nanomachines whose motion is read out optically (chiral plasmonics, FRET), and, increasingly, synthetic-cell systems -- DNA-based pores and a programmable DNA-origami nanosyringe for directed membrane translocation, the latter published jointly with Nussberger's biophysics group at Stuttgart. The through-line is building nanoscale machines that both actuate and report. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), the relevance is on the biosensing axis: this is the group that can put a nanoscale probe exactly where you want it on or through a membrane, which is the delivery problem that in-cell quantum sensing keeps running into. Preferred-attribute note: nanofabrication is heavily used, but the emphasis is on single-molecule optical readout rather than device manufacture per se.
Monzel holds the biophysics/biophotonics professorship at Stuttgart's 2nd Institute of Physics. The group develops multiparametric imaging spectroscopy and high-resolution light microscopy -- combining super-resolution, fluorescence-fluctuation and lifetime-resolved methods -- to read out several observables at once in living cells and in biomimetic model membranes, and pairs this with magnetic nanoparticles used to apply and sense forces on cell-surface receptors (magnetogenetic control of signalling). Single-molecule analysis inside cells is an explicit focus. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), this is the closest thing at Stuttgart to a natural biological host for in-cell quantum sensing: the group already does single-molecule-resolution live-cell imaging and already works with magnetic nanoparticles, so nanodiamond relaxometry/thermometry would slot in with the readout stack it already runs. Relatively new appointment -- good moment to join.
Natrajan's group develops luminescent lanthanide complexes for chemical and biological sensing. Research directions: (1) Time-gated lanthanide luminescence sensing — long-lifetime Eu3+, Tb3+, and Yb3+ complexes with millisecond emission lifetimes for background-free sensing in cells and tissue; (2) Intracellular sensing — luminescent probes for sensing O2, pH, viscosity, and specific enzymes inside living cells with spatiotemporal resolution; (3) Chiral discrimination — circularly polarized luminescence (CPL) from Eu3+ complexes for enantioselective sensing; (4) Responsive probes — switchable lanthanide complexes as ratiometric sensors for biomedical imaging. The long-lifetime emission enables time-gating strategies analogous to quantum sensing protocols.