Technique - (15) Nanoparticle / nanocrystal synthesis

Type: Fabrication

Description: Colloidal synthesis of size- and shape-controlled inorganic nanocrystals and quantum dots.

Department(s)/lab(s): Physics & Astronomy – Biophysics | Nguyen Lab (Nanomaterials for Biosensing) @ UCL
Summary:

Nguyen's group at UCL (based at Royal Institution) focuses on magnetic and fluorescent nanoparticles for biomedical sensing and therapy. Research directions: (1) Magnetic nanoparticle synthesis — iron oxide (SPION) and other magnetic nanoparticles with controlled size, shape, and surface chemistry for MRI contrast and magnetic hyperthermia; (2) Biosensing platforms — functionalized nanoparticles as MRI-detectable sensors for specific biomolecular targets; magnetic particle imaging (MPI) for real-time tracking; (3) Plasmonic nanoparticles — gold nanoparticles for optical biosensing and photothermal therapy; (4) Fluorescent nanoparticles — QD- and dye-conjugated probes for live-cell imaging. Relevant to quantum sensing through magnetic nanoparticle platforms.

Department(s)/lab(s): Physics | LuMIn - Nanoplasmonics & Ultrafast (Palpant) @ ENSPS
Summary:

Palpant (current LuMIn director) studies ultrafast optical response and thermoplasmonics of metal nanoparticles - photothermal nanoscale heat sources and sensors for photonics and biomedicine. Primary appointment CentraleSupelec; based at the ENS Paris-Saclay LuMIn site. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is adjacent through plasmonic photothermal transduction and sensing.

Department(s)/lab(s): School of Physics | Quantum Nanoscience Laboratory @ USyd
Summary:

Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale — custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering — a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.

Department(s)/lab(s): School of Chemistry | Tilley Nanomaterials and Electron Microscopy Group @ UNSW
Summary:

Tilley directs the UNSW Electron Microscope Unit and runs a nanomaterials group whose distinctive capability is in-situ liquid-cell TEM: watching nanoparticle nucleation, growth and catalytic transformation in real time inside the microscope, in liquid, rather than inferring mechanism from before-and-after snapshots. The synthetic side produces magnetic and plasmonic nanoparticles used as biosensor labels and MRI contrast agents, largely in collaboration with Gooding and Reece. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the group is a supplier and characteriser of the nanoparticle probes that in-cell quantum sensing depends on — including the magnetic-nanoparticle labels whose stray fields a pT/sqrt(Hz) NV sensor would actually detect — and the liquid-cell TEM capability is a rare way to validate what those particles are doing in situ. Borderline inclusion (materials characterisation rather than sensing), kept for the collaborative infrastructure it represents.

Department(s)/lab(s): Department of Synthesis of Macromolecules | Weil Department - Synthesis of Macromolecules @ MPIP
Summary:

Weil directs the Synthesis of Macromolecules department at the MPI for Polymer Research in Mainz (co-located with JGU, with which the department collaborates closely). The quantum-sensing core of her programme is nanodiamond: in 2026 her group published a bottom-up route that converts molecularly defined nanographenes into ultrasmall, size-uniform nanodiamonds under HPHT, incorporating SiV and GeV colour centres during synthesis rather than by post-hoc implantation -- addressing the long-standing problem that milled detonation nanodiamonds have poor size control and damaged surfaces. Alongside this sits a mature nanodiamond biosensing line: surface bioconjugation and nanogel encapsulation, T1 relaxometry for free-radical detection in single mitochondria and in cells, nanoscale thermometry and photothermal theranostics. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), this group is attacking the material bottleneck directly -- if you want NV/SiV ensembles with controlled size, surface and coherence for in-cell sensing, this is the synthesis end of that pipeline, and it feeds spin-readout collaborators at Ulm (Jelezko/Kubanek).