Treps leads the Multimode Quantum Optics group at LKB. Research directions: (1) Multimode quantum frequency combs — synchronously pumped OPO (SPOPO) generates entangled networks of squeezed modes with configurable graph structure; first demonstration of quantum frequency comb with multimode squeezing (PRL 2012); (2) Quantum-enhanced multiparameter estimation — quantum Fisher information and multimode squeezing for simultaneous beyond-shot-noise parameter estimation (e.g., frequency comb spectral centroid and energy, PRX 2020); (3) Non-Gaussian quantum states — heralded generation of non-Gaussian cluster states for CV quantum computing; (4) Quantum metrological inequalities — relating non-locality to parameter estimation. Spin-off: Cailabs (multimode fiber light-shaping for telecom and industrial lasers). Co-director of QICS. ERC-funded.

Waigh's group applies advanced optical and biophysical techniques to study complex biological fluids and single molecules. Research directions: (1) Microrheology — diffusing wave spectroscopy and optical trapping microrheology to measure viscoelastic properties of biopolymer networks and cytoplasm; (2) Antibody / protein dynamics — tracking single-molecule diffusion of antibodies and receptors in complex biological environments using fluorescence; (3) Non-linear flows of antibodies — studying anomalous diffusion and aggregation of therapeutic antibodies; (4) Neutron and X-ray scattering — structural characterization of complex biofluids at PSI facilities. Bridges soft matter physics and single-molecule biosensing.

Wickham builds DNA origami nanostructures — programmable, self-assembling scaffolds with nanometre-precision addressability — and uses them as molecular machines, drug-delivery vehicles and, most relevantly, as rulers and probes for single-molecule measurement. DNA origami is the standard platform for DNA-PAINT super-resolution and for positioning fluorophores, nanoparticles or spin labels at defined separations, and her group works on dynamic, reconfigurable devices that respond to biological triggers. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — DNA origami is the leading candidate technology for positioning target molecules at a controlled standoff from a near-surface NV ensemble, which is the central geometric problem in pushing NV nanoscale NMR and DEER from pT/sqrt(Hz) ensembles down to single-molecule sensitivity. Genuinely complementary skill set for a quantum-sensing candidate.

Yang's experimental physical chemistry lab designs new instrumentation to track single proteins, nanoparticles, and other emitters in three dimensions in real time within complex, heterogeneous environments, including a recent time-gated two-photon platform for high-speed 3D single-particle tracking. His group applies these single-molecule tracking and orientation-resolved imaging tools to protein conformational dynamics, functional nanostructures, and active-matter systems.

Yildiz uses nanometer-precision single-molecule fluorescence and optical/magnetic tweezers (FIONA-type localization) to resolve the stepping mechanisms of cytoskeletal motor proteins such as myosin, kinesin, and dynein in living cells.