Summary: UChicago anchors the Chicago Quantum Exchange (CQE) — the US's most concentrated quantum ecosystem, partnering Argonne, Fermilab, JPL, and multiple Chicago-area universities. The Pritzker School of Molecular Engineering (PME) hosts world-class quantum sensing groups: Bhave (levitated optomechanics, quantum-limited force sensing); Bhave/Schuster (superconducting qubit sensing); Bhave/Bhave connections across mechanical and electromagnetic sensing. The Department of Physics hosts Gregor Engel's group on quantum coherence in biology. The James Franck Institute bridges physics and chemistry for quantum optical sensing. Argonne's Advanced Photon Source and Fermilab's quantum sensing programs are accessible to UChicago postdocs via joint appointments.
Notes: Top private R1; strong quantum ecosystem via Chicago Quantum Exchange. PME, Physics, Chemistry, and A&A all active. Partner institutions include Argonne and Fermilab.
Studies atomically thin 2D quantum materials and their sensing applications. Directions: (1) tr-ARPES and ultrafast spectroscopy of non-equilibrium electronic dynamics in TMDs and graphene heterostructures; (2) 2D material nanophotonic devices for light sensing and emission; (3) wafer-scale CVD growth of hBN, MoS2, WSe2 for integrated quantum devices; (4) scanning probe characterization of local optical and electronic properties. Key tool: time-resolved photoemission as ultrafast electronic structure sensing.
Works on quantum-limited sensing for astroparticle physics. Directions: (1) Pierre Auger Observatory — UHE cosmic ray composition and spectrum via radio and fluorescence detection; (2) liquid argon dark matter detectors; (3) co-PI DARPA QuSeN (2025) — quantum sensing of neutrinos using phonon-coupled SC qubit sensors with Cleland and Chou. KICP member.
Rock builds custom single-molecule fluorescence microscopes and optical tweezers to directly watch individual myosin motors move along the actin cytoskeleton in vitro and in living cells, quantifying motor stoichiometry, force generation, and navigation rules that organize cell shape and motility. Where NV-ensemble quantum sensors read out spin ensembles magnetically at pT/sqrt(Hz) sensitivity via DEER/NMR/T1 protocols, Rock's approach achieves single-fluorophore and single-motor mechanical/positional resolution using all-optical single-molecule methods.
Applies advanced single-molecule biosensing to study the cyanobacterial circadian clock — the only fully reconstitutable in vitro biochemical oscillator. Directions: (1) single-molecule FRET and fluorescence imaging to track conformational states of KaiC ATPase during clock cycles with single-protein resolution; (2) single-molecule reconstitution of the complete KaiA/KaiB/KaiC oscillator; (3) mathematical modeling of biochemical oscillation. Technique focus: single-molecule fluorescence as quantitative biosensing tool for protein conformational dynamics. Joint appointment Microbiology.
Uses single-molecule spectroscopy, optical trapping, and advanced imaging to study nanoscale systems. Directions: (1) orientation-resolved single-molecule spectroscopy using polarization-controlled excitation and detection; (2) optical trapping of individual nanoparticles and viruses to study force-dependent dynamics; (3) plasmon-enhanced single-molecule detection and imaging beyond diffraction limit; (4) ultrafast spectroscopy of nanoscale energy transfer.
Research centers on manipulating and measuring single molecules with quantum-level precision. Primary platform: ABEL trap (Anti-Brownian ELectrokinetic trap) for single-molecule confinement in free solution without surface tethering, enabling measurement of spectroscopic identity, molecular dynamics, and nanoscale energy transfer at femtomolar concentrations. Also develops orientation-resolved single-molecule imaging and single-molecule FRET for photoadaptation in photosynthetic systems and nanoscale immune cell signaling. QuBBE member. PhD Physics UChicago; joined 2024.
Pioneers living bioelectronics integrating semiconductor nanostructures with biological systems. Primary directions: (1) silicon nanowire / nanoporous silicon photoelectrochemical interfaces for optical neuromodulation with subcellular spatial resolution; (2) intracellular silicon nanowire probes for recording action potentials from individual organelles; (3) bioinspired flexible mesh electronics for in vivo neural and cardiac interfaces. QuBBE member. 2026 Marian and Stuart Rice Research Award.
Uses ultrafast multidimensional spectroscopy to study structural dynamics of biomolecules. Directions: (1) 2D IR spectroscopy of protein folding, water dynamics, and membrane systems with sub-100-fs time resolution; (2) single-molecule FRET for resolving conformational heterogeneity in proteins and nucleic acids; (3) development of ultrafast mid-IR laser sources and pulse shaping for 2D spectroscopy. Resolves dynamics inaccessible to other methods.
Builds radio and mm-wave quantum-limited sensing instruments for high-energy astrophysics and cosmology. Directions: (1) PUEO — balloon-borne radio Cherenkov (Askaryan) detector for ultra-high-energy cosmogenic neutrinos; (2) RNO-G — ground-based radio neutrino array at Summit Station, Greenland; (3) UHE cosmic ray radio detection methodology; (4) CMB instrumentation (BICEP/Keck, SPT, CMB-S4). 2025 APS Fellow; 2022 Moore EPII award. Director KICP.
Experimental astroparticle physicist developing radio-based detection of ultra-high-energy cosmic rays. Directions: (1) HAWC — high-altitude water Cherenkov detector for gamma-ray and cosmic ray sensing; (2) IceTop surface array at IceCube for cosmic ray composition at the knee; (3) radio detection of cosmic-ray-induced air showers (Askaryan emission) as a technique for large-scale UHE cosmic ray sensing. Enrico Fermi Institute member.