Jeroen Kalkman develops optical tomography and spectroscopy methods for biomedical imaging. Research: (1) Fourier-domain OCT including spectroscopic OCT for tissue structural and functional imaging; (2) novel light sources and detectors for skin cancer detection (NWO KIC project NextDeLights); (3) scattering media imaging. His work is relevant to advanced biosensing with optical coherence.
Kaminski's Laser Analytics Group develops laser-based super-resolution and fluorescence-lifetime imaging methods (STED, SIM, dSTORM, FLIM) and applies them, with long-time collaborator Gabriele Kaminski Schierle, to visualise amyloid protein aggregation in live cells and organisms as a route to understanding neurodegenerative disease; the group also directs the EPSRC Centre for Doctoral Training in Sensor Technologies.
Kaminski Schierle heads the Molecular Neuroscience Group, applying super-resolution and functional fluorescence imaging (developed with Clemens Kaminski) to gain molecular-level understanding of protein misfolding in Alzheimer's, Parkinson's and Huntington's disease models, including live-cell and whole-organism (C. elegans) imaging of amyloid aggregation.
Kuimova pioneered the use of fluorescent 'molecular rotor' probes combined with fluorescence lifetime imaging (FLIM) to quantitatively map intracellular microviscosity in live cells and tissue, with applications spanning photodynamic therapy, membrane biophysics and G-quadruplex DNA imaging.
McGinty develops fluorescence lifetime imaging (FLIM) instrumentation, including endoscopic and widefield FLIM systems, for applications in cancer diagnosis and metabolic/functional imaging.
Neil works on advanced optical microscopy techniques including structured-illumination and super-resolved (STED/SIM) imaging, and wavefront-based aberration correction, within Imperial's Photonics/Biophotonics group.
Marie-Claire Schanne-Klein (DR1 CNRS, LOB) specializes in polarized SHG and THG microscopy for structural tissue imaging. Research: (1) polarimetric SHG imaging of collagen fibril organization — molecular orientation mapping; (2) THG microscopy for myelin and red blood cell imaging; (3) structural and functional label-free imaging of connective tissues; (4) multi-scale SHG/THG analysis of biopolymer structure. SHG expert in LOB.
Smith runs Melbourne's time-resolved fluorescence facility and specialises in the information channels most people throw away: fluorescence lifetime, anisotropy decay and its orientational content, and single-molecule photophysics, applied to organic semiconductors, energy-transfer systems and biological samples. The group builds its own confocal microspectroscopy instrumentation for time-resolved anisotropy imaging and single-molecule detection. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — lifetime- and orientation-resolved fluorescence is the principal orthogonal contrast mechanism to spin-based sensing, and his instrumentation is the natural correlative partner for NV-ensemble DEER/relaxometry experiments at pT/sqrt(Hz) that need an independent optical readout of the same specimen. Preferred attribute present: orientation- and lifetime-resolved methods.
Chiara Stringari (CRCN CNRS, LOB) develops FLIM-based metabolic imaging. Research: (1) fluorescence lifetime imaging microscopy (FLIM) of NAD(P)H and FAD in live tissue for label-free metabolic mapping; (2) phasor analysis of FLIM data for cellular metabolism states; (3) imaging of myelin dynamics using label-free nonlinear microscopy; (4) metabolic imaging in development and disease. 2025 paper on myelin in Optica.
Willy Supatto (DR2 CNRS, LOB) develops ultrafast two-photon light-sheet microscopy for quantitative in vivo imaging of embryo development and tissue dynamics. Research: (1) two-photon SPIM (light-sheet) for volumetric live imaging in zebrafish embryos; (2) SHG imaging of fibrillar proteins; (3) polarization-THG microscopy of structural anisotropy; (4) photodamage in multiphoton imaging. Part of key LOB team with Beaurepaire.