Research Areas - (4) FLIM Endoscopy for In-Vivo Cancer Diagnostics

Full path: Biology > Biophysics > FLIM / Super-Resolution Biophotonics > FLIM Endoscopy for In-Vivo Cancer Diagnostics

Department(s)/lab(s): Physics (Cavendish Laboratory) | VISION Lab @ Cambridge
Summary:

Bohndiek's VISION Lab, run jointly between the Cavendish Laboratory and the Cancer Research UK Cambridge Institute, develops low-cost optical and photoacoustic imaging technologies to study the tumour microenvironment and vasculature, with a strong translational focus on early cancer detection (e.g. hyperspectral endoscopy for oesophageal cancer). The lab is part of a large interdisciplinary team and regularly recruits postdoctoral researchers.

Department(s)/lab(s): Physics / LKB / Collège de France | Bose-Einstein Condensates (Dalibard/Yefsah) @ ENS Paris
Summary:

Jean Dalibard's BEC group at LKB studies quantum gases, BEC, and strongly correlated quantum systems. Research: (1) 2D Bose gases and Berezinskii-Kosterlitz-Thouless transition; (2) gauge fields for neutral atoms — synthetic magnetism; (3) quantum simulation with ultracold atoms. Dalibard is a foundational figure in cold-atom physics; his group at LKB/Collège de France is relevant through quantum gas experiments tied to quantum simulation and precision measurement. Borderline case included given BEC foundations for sensing.

Department(s)/lab(s): Physics – Photonics Group | Biophotonics Group – Photonics Department (French) @ Imperial
Summary:

French is Professor and former Head of the Photonics Group (2001–2013). His group at Imperial (with Dunsby and Neil) develops multidimensional fluorescence imaging technology for life sciences and clinical applications. Research portfolio: (1) FLIM β€” wide-field time-gated FLIM using gated optical intensifiers and TCSPC for single-cell FRET-based biosensing of protein-protein interactions, cell signalling (kinase activity), and drug-target engagement in multi-well plates; (2) Super-resolved microscopy β€” STED, easySTORM (lower-cost STORM), and SIM+FLIM for mapping molecular function to biological nanostructure below the diffraction limit; (3) FLIM endoscopy β€” flexible wide-field FLIM endoscopes for label-free cancer diagnostics (autofluorescence lifetime) and osteoarthritis cartilage; (4) Open-source imaging β€” automated multiwell plate FLIM reader for high-content drug screening. Satellite lab at Francis Crick Institute.

Department(s)/lab(s): Physics / Laboratoire Charles Fabry (IOGS/X) | Quantum Gases Group LCF (Westbrook/Aspect Lab) @ X
Summary:

Christoph Westbrook co-heads the Quantum Gases group at LCF/IOGS. Research: (1) metastable helium (He*) BEC and ultracold atomic gases β€” atom optics, Bose-Hubbard physics, Anderson localization; (2) correlated atom pair production via four-wave mixing for quantum atom optics sensing; (3) atom laser and matter-wave interferometry. The group pioneered the He* BEC and uses correlated atom pairs for quantum sensing analogous to two-photon quantum optics.