Perkins' group advances precision single-molecule force spectroscopy - ultra-stable atomic force microscopy and optical traps - to resolve the folding, dynamics and mechanics of individual proteins and nucleic acids with improved force, spatial, and temporal precision. For context, this complements the established paradigm of NV-diamond ensemble magnetometry (Hahn-echo/DEER, nanoscale NMR, T1 relaxometry) operating near pT/√Hz sensitivity.