Boccaletti develops and exploits high-contrast coronagraphic imaging instrumentation for direct detection and characterization of exoplanets and circumstellar debris disks, including the four-quadrant phase-mask coronagraph built at Observatoire de Paris-PSL now flying on JWST's MIRI instrument, which recently resolved the inner dust belt and all four planets of the HR 8799 system in the mid-infrared.

Lagrange is a leading figure in direct-imaging exoplanet science, using the VLT/SPHERE extreme-adaptive-optics coronagraph (which she helped design and exploit) to detect and characterize young giant planets around nearby stars, most notably the beta Pictoris planetary system, and to study debris-disk and planet-formation signatures such as non-common-path aberration correction algorithms for next-generation direct-imaging instruments.

Landragin directs SYRTE and its Cold Atom Interferometry and Inertial Sensors team, which develops light-pulse atom interferometers as absolute gravimeters and gyroscopes: the Cold Atom Gravimeter (CAG), whose single-laser pyramid-reflector design he co-invented and commercialized through the start-up Muquans (now Absolute Quantum Gravimeter, AQG), and continuously-operating cold-atom gyroscopes reaching record joint sensitivity. Applications span geodesy, hydrology, volcano monitoring and inertial navigation. He received the CNRS Innovation Medal in 2020.

Le Targat co-leads SYRTE's Optical Frequency Metrology team, which built and continuously operates two independent strontium optical lattice clocks alongside a mercury lattice clock, comparing them at the 10^-16 to 10^-17 level and to SYRTE's caesium fountain primary standards. This work underpins the prospective redefinition of the SI second on an optical transition and supports frequency-transfer, geodesy and fundamental-physics tests via fiber links to other French metrology laboratories.