Yao works at the interface of theoretical and experimental many-body physics and quantum sensing, using dense NV-diamond spin ensembles and Hamiltonian engineering to push magnetometry and nanoscale NMR beyond standard-quantum-limit sensitivities. His work is a direct extension of the original NV ensemble quantum sensing experiments (DEER, nanoscale NMR, T1 relaxometry) that achieved pT/√Hz sensitivity, adding many-body-enhanced protocols and error-correction-assisted sensing on top of that foundation.